Which cells are responsible for bone resorption and originate from macrophage-lineage?

Which cells are responsible for bone resorption and originate from macrophage-lineage?

• A. Osteogenic Cells
• B. Osteoblasts
• C. Osteocytes
• D. Osteoclasts

Answer: (D)

Bone resorption is carried out by osteoclasts, which come from the macrophage-lineage of blood cells. These large, multinucleated cells attach to the bone surface and create a sealed zone where they secrete acid and proteolytic enzymes to dissolve mineral and organic matrix, forming Howship’s lacunae. This resorption process is balanced by osteoblasts, which form new bone, and by osteocytes, mature cells embedded in bone that help regulate remodeling. Osteoclasts originate from hematopoietic precursors, the same lineage as macrophages, through fusion of monocytes. So, the cells responsible for bone resorption and originating from macrophage-lineage are osteoclasts.

Bone resorption is carried out by osteoclasts, which come from the macrophage-lineage of blood cells. These large, multinucleated cells attach to the bone surface and create a sealed zone where they secrete acid and proteolytic enzymes to dissolve mineral and organic matrix, forming Howship’s lacunae. This resorption process is balanced by osteoblasts, which form new bone, and by osteocytes, mature cells embedded in bone that help regulate remodeling. Osteoclasts originate from hematopoietic precursors, the same lineage as macrophages, through fusion of monocytes. So, the cells responsible for bone resorption and originating from macrophage-lineage are osteoclasts.